Experimental Model of Zymosan-Induced Arthritis in the Rat Temporomandibular Joint: Role of Nitric Oxide and Neutrophils
Figure 3
Photomicrographs of the histopathological analysis of TMJ and periarticular tissues. Photomicrographs of TMJ and periarticular tissues of nontreated (a, b, c) and L-NAME 100 mg/kg or 1400 W 1 mg/kg treated animals (d, e). (a) Normal group TMJ (40x). (b) Arthritic rats, TMJ induced by zymosan 2 mg (40x) showing inflammatory cell influx in the synovial membrane, periarticular tissue, musculoskeletal tissue, and synovial membrane thickness. (c) Synovial tissue of arthritic rats injected with zymosan 2 mg (400x) showing edema and inflammatory cell influx with polymorphonuclear predominance. (d) TMJ of arthritic rats injected with zymosan 2 mg and treated with L-NAME 100 mg/kg (40x). (e) TMJ of arthritic rats injected with zymosan 2 mg treated with 1400 W 1 mg/kg (40x). C: condyle; AC: articular cartilage; AD: articular disc; SM: synovial membrane; PAT: periarticular tissue; MET: musculoskeletal tissue. Hematoxylin and eosin staining.
