Review Article
Proteomics in Molecular Diagnosis: Typing of Amyloidosis
Table 1
Common types of amyloidosis and treatment options [
9,
64].
| Amyloid protein1 | Precursor | Systemic (S) or localized (L) | Organ involvement | Aetiology | Treatment options |
| AL | Immunoglobulin kappa or lambda light chain | S, L | Cardiac, renal, hepatic, PNS, and soft tissues | Primary or myeloma associated | Chemotherapy, stem cell transplant | ATTR | Transthyretin | S | Cardiac, PNS, GIT, CTS | Hereditary | Liver transplant | ATTR | Transthyretin | S | Cardiac, CTS | Senile | Supportive care | AA | (Apo)serum amyloid A | S | Renal | Secondary to chronic inflammation | Control inflammation |
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1Recommended amyloid protein nomenclature includes prefix A [3]. PNS: peripheral nervous system; GIT: gastrointestinal tract; CTS: carpal tunnel syndrome.
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