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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 756864, 1 page

Cytotoxic T Lymphocytes and Vaccine Development 2011

1Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
2Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
3Department of Veterinary Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing 100083, China
4Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA

Received 12 February 2012; Accepted 12 February 2012

Copyright © 2011 Zhengguo Xiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Research on CTLs has been booming in recent years—there are more than 250 papers related to CD8 T-cells published every month. With such rapid advancement in this particular aspect of immunology alone, it is important to summarize and report information on this hot topic in a timely and organized fashion. Although the submission window for this issue was open for a significantly shorter period compared to the last issue on this topic, we received an even broader depth of reviews on many different aspects of CTL function and application including some focused on the development of vaccines against cancer and viral infections. For example, by reviewing mechanisms of T-cell evasion by tumors, novel approaches were proposed to improve the anticancer capacity of T-cells including the adoptive transfer of T-cells as an alternative methodology to deliver tumor-associated antigens and DC-associated molecules. In addition, vaccination strategies against infectious diseases targeting CTLs and the PD-1/PD-L1 pathway and as well as the induction of effector CTL responses in mucosal sites are also proposed. Lastly, a new detection method of virus-specific CTLs in filovirus infection and a model system reported to target both CTL and CD4 epitopes in viral infections are also described.


In closing, we wish to thank all of the authors for their high level of enthusiasm in providing high quality manuscripts to support this special issue and appreciate their effort and time spent processing their manuscripts. We also extend much gratitude to all of the reviewers, most of whom reviewed at least two versions of the same manuscript, for their time and effort. We hope the scientific information presented within this special issue will be helpful to both CTL aficionados and the broader immunological community and promote new avenues of exploration for scientists studying CTLs in the context of vaccine development.

Zhengguo Xiao
Kim Klonowski
Hanchun Yang
Julie Curtsinger