Figure 3: (a) Interstitial fibrosis as determined by Masson’s Trichrome staining in control and doxorubicin-treated hearts. (b) and (c) Representative histomicrographs of myocardial architecture in control and doxorubicin-treated hearts. In control animals, the outlines of individual myocytes are apparent. Interstitial endo- and perimysium are well established and clearly visible. In doxorubicin treated animals, normal myocyte borders are not apparent, and connective tissue is largely absent. 40x, white μm, * versus control. LV, left ventricle; RV, right ventricle; /group.