Diagnosis and Prognostication of Ductal Adenocarcinomas of the Pancreas Based on Genome-Wide DNA Methylation Profiling by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification

Table 3

Eleven BAC clones that were able to discriminate patients belonging to the early-relapse group from those belonging to the no-relapse group in the learning cohort with 100% specificity.

BAC clone ID∗	Location	Cutoff value (CV)	DNA methylation status∗∗	Sensitivity (%)	Specificity (%)
RP11-101J8	1q23.1	0.98	CV<	47.1	100
RP11-137N24	1q25.1	1.08	CV<	58.8	100
RP11-180L21	2p21	0.97	CV<	37.5	100
RP11-91K8	3q22.1	0.84	CV<	41.2	100
RP11-89E2	4q28.2	0.99	CV<	58.8	100
RP11-81B23	5p14.3	0.99	CV>	50.0	100
RP11-373P23	10q21.1	1.04	CV<	29.4	100
RP11-666F17	12p11.23	1.15	CV>	58.8	100
RP11-165B11	16p13.13	1.29	CV>	76.5	100
RP11-236B14	19q13.33	0.87	CV>	52.9	100
RP11-92A14	21q21.1	1.03	CV<	53.3	100

∗CV>, when the signal ratio was lower than the cutoff value, the sample of cancerous tissue was considered to originate from a patient who would suffer early relapse; CV<, when the signal ratio was higher than the cutoff value, the sample of cancerous tissue was considered to originate from a patient who would suffer early relapse.