Clinical Therapeutics in Pregnancy

Table 1

Pregnancy-induced physiologic changes during near term.

System [ref.]	Parameter	Non; pregnant	Pregnant
Cardiovascular [18, 19]	Cardiac output (L/min)	4.0	7.0
	Heart rate (beats per min)	70	90
	Stroke volume (mL)	65	85
	Plasma volume (L)	2.6	3.5
	Colloid osmotic pressure (mmHg)	22.0	18.2
	Total peripheral arterial resistance (dyne s cm^−5)	1530	1210
Respiratory [20]	Total lung capacity (mL)	4225	4080
	Residual volume (mL)	965	770
	Tidal volume (mL)	485	680
	Minute O2 uptake	201	265
Liver [21]	Portal vein blood flow (L/min)	1.25	1.92
	Hepatic artery blood flow (L/min)	0.57	1.06*
Renal [22]	Glomerular filtration rate (mL/min)	97	144
	Creatinine (mg/dL)	0.7	0.5

*Difference was not statistically significant.