Research Article

Mutation of Herpesvirus Saimiri ORF51 Glycoprotein Specifically Targets Infectivity to Hepatocellular Carcinoma Cell Lines

Figure 9

Somatostatin receptor 1 is not required for HVS mORF51 cell entry. Two pancreatic cancer cell lines (MiaPaCa, and Panc1) were stably transfected with a construct expressing the SSTR1 gene. 48 h after infection with HVS mORF51, the cell lines expressing SSTR1 showed no increase in GFP expression as measured by flow cytometry, indicating that the recombinant virus does not interact with this receptor to enter the cell ( ).
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