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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 790132, 9 pages
http://dx.doi.org/10.1155/2011/790132
Review Article

Metabolomic Profiling for Identification of Novel Potential Biomarkers in Cardiovascular Diseases

1Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, 45071 Toledo, Spain
2Department of Immunology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain
3Department of Biochemistry and Molecular Biology I, Universidad Complutense, 28040 Madrid, Spain

Received 11 June 2010; Revised 11 August 2010; Accepted 12 November 2010

Academic Editor: Mika Ala-Korpela

Copyright © 2011 Maria G. Barderas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metabolomics involves the identification and quantification of metabolites present in a biological system. Three different approaches can be used: metabolomic fingerprinting, metabolic profiling, and metabolic footprinting, in order to evaluate the clinical course of a disease, patient recovery, changes in response to surgical intervention or pharmacological treatment, as well as other associated features. Characteristic patterns of metabolites can be revealed that broaden our understanding of a particular disorder. In the present paper, common strategies and analytical techniques used in metabolomic studies are reviewed, particularly with reference to the cardiovascular field.