Role of Positive Selection in Functional Divergence of Mammalian Neuronal Apoptosis Inhibitor Proteins during Evolution

Table 3

The prediction model evaluation.

Type	C-score	TM-score	RMSD	No. of decoys	Cluster density
Human NAIP	−1.24	0.56 ± 0.15	12.8 ± 4.2 Å	93	0.1275
Mouse NAIP2	−1.69	0.50 ± 0.15	14.2 ± 3.8 Å	99	0.0787

Note: C-score is a confidence score for estimating the quality of predicted models by I-TASSER. It is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [−5,2], where a C-score of higher value signifies a model with a high confidence and vice versa.
TM-score and RMSD are known standards for measuring structural similarity between two structures which are usually used to measure the accuracy of structure modeling. TM-score >0.5 indicates a model of correct topology.