The Application of Three-Dimensional Collagen-Scaffolds Seeded with Myoblasts to Repair Skeletal Muscle Defects

<table>Three months after implantation, evaluation of the regenerative capacity of the seeded scaffolds. A hematoxylin and eosin staining revealed a large area of fibrosis in the muscle graft ((a) and (b)<i>, sk</i>).  However, within the muscle graft despite the area of fibrosis, we detected regenerating myofibers ((b),<i> arrows</i>), and large quantities of dystrophin-positive myofibers ((c),<i> arrows</i>). Within the areas of regeneration, revascularization was detected through the visualization of CD31-positive cells ((d)<i> green/arrows</i>).</table>

BioMed Research International

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Figure 7

Figure 7: The Application of Three-Dimensional Collagen-Scaffolds Seeded with Myoblasts to Repair Skeletal Muscle Defects 