Table 3: Effects of HDAC inhibitor on the process of autophagy.

MechanismsHDAC inhibitorsCell lines*Detection methodsRef

mTORSAHAESS-1Phosphorylation (mTOR)[33]
AIFFK228MRTsiRNA (AIF)[34]
ROSSAHAK562, LAMA84N-acetyl-cysteine, chloroquine[35]
H40, SAHAPC-3M, HL-60mRNA, protein expression[36]
HDAC1FK228HeLasiRNA (HDAC1)[37]
HDAC6TubacinMEFsiRNA (HDAC6)[38]
MitochondriaLBH589, LAQ824Eμ-myc lymphomaKnockout (Apaf-1, caspase-9)[39]

*ESS-1: endometrial stromal sarcoma cells; LAMA84: human chronic myeloid leukemia; MEF: mouse embryonic fibroblasts; MRT: malignant rhabdoid tumors.