Muscle Atrophy and Motor Neuron Degeneration in Human NEDL1 Transgenic Mice
Figure 4
Overexpression of hNEDL1 induced neuron degeneration in lumbar spinal cord and skeletal muscle atrophy. Bodian-stained section of frontal cortex, hippocampus, striatum (bar = 50 m), and lumbar spinal cord (bar = 20 m). Degenerated motor neurons and decreased axon are observed in the lumbar spinal cord in the hNEDL1-Tg mouse. The numbers of motor neuron in the total motor neuron and in the degenerated motor neuron from wild-type mice (white bar: ) and hNEDL1-Tg mice (black bar: ) from the age of six to fifteen months were shown. Data are mean ± SEM ().
