Muscle Atrophy and Motor Neuron Degeneration in Human NEDL1 Transgenic Mice
Figure 5
Overexpression of hNEDL1 induced neuron degeneration in lumbar spinal cord and skeletal muscle atrophy. (a) Haematoxylin and eosin-stained section of skeletal muscle from 6-month-old wild-type and hNEDL1-Tg mice (bar = 100 m). Muscle atrophy is observed in the hNEDL1-Tg mouse. (b) Immunochemistry study, by using Iba-1 antibody, represented the microglia cells in spinal cord tissue. The numbers of total microglia cells and the activated microglia cells, which were judged by the morphologic change, were counted.
