A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, and In Vivo Antitumor Efficacy and Safety

Table 4

The rank of allergic reactions for each dog.

No.	Control group	Paclitaxel injection treatment group	Paclitaxel microemulsion treatment group	Paclitaxel injection premedication treatment group	Paclitaxel microemulsion premedication treatment group
1	—	+++	++	++	+
2	—	+++	++	++	+
3	—	+++	++	++	+
4	—	+++	++	++	+
5	—	+++	++	++	+
6	—	+++	+++	+++	+
			∗∗	∗∗‡‡	††§§

∗∗𝑃<.01, Paclitaxel injection treatment group versus Paclitaxel microemulsion treatment group or Paclitaxel injection premedication treatment group.
‡‡𝑃>.05, Paclitaxel microemulsion treatment group versus Paclitaxel injection premedication treatment group.
††𝑃<.01, Paclitaxel microemulsion treatment group versus Paclitaxel microemulsion premedication treatment group.
§§𝑃<.01, Paclitaxel injection premedication treatment group versus Paclitaxel microemulsion premedication treatment group.