A New Normalizing Algorithm for BAC CGH Arrays with Quality Control Metrics

Table 1

Each step in the “SmoothArray” normalization process for CGH microarray experiments. Each step is detailed in Section 2.3.

Bias	Normalization method	Description
Intensity	Global Loess	Fit 𝑀 according to intensity values 𝐴
Spatial	Spatial Kernel smoother	Fit a spatial smoother to 𝑀 values after CBS [37]
Spotting process	Median	Compute a median to estimate the pin, plate, plate row, and plate column effects