Upregulated Expression of Cytotoxicity-Related Genes in IFN-𝜸 Knockout Mice with Schistosoma japonicum Infection

Table 2

Signal intensities of some characteristic genes in spleen cells, purified CD8⁺ and NK cells from 6-week Schistosoma japonicum-infected mice.

Gene Symbol	Probe Set ID	Spleen cells			Purified CD8^+ cells			Purified NK cells
		SI* of IFNg KO	SI of WT	Change**	SI of IFNg KO	SI of WT	Change**	SI of IFNg KO	SI of WT	Change**
ccl2	1420380_at	241.3	48.3	Increase	80.5	54.1	No change	219.8	43	Increase
ccl4	1421578_at	674.3	293.7	No change	2028.4	874.2	Increase	6176.4	2540.6	Increase
ccl5	1418126_at	19335.4	6000.8	Increase	32722	27917.8	No change	25966.1	29725.3	No change
ccl9	1417936_at	3048.6	2043.1	Increase	939.3	493.4	Increase	14887.6	10318.9	Increase
ccr2	1421188_at	414.5	141.6	No change	586.5	211.5	Increase	4102.4	1825.7	Increase
ccr3	1422957_at	141.5	97	No change	247	29.4	Increase	575.3	130.2	Increase
ccr5	1424727_at	594.2	257.3	Increase	1422.7	1105	Increase	1757.1	1424.8	Increase
cxcl2	1449984_at	3436.5	1584.8	Increase	2948.7	690.5	Increase	5645.8	1727.6	Increase
cxcr6	1422812_at	2547.3	438.4	Increase	6390	1782.7	Increase	8213.3	2695.1	Increase
csf1r	1419873_s_at	3946.4	2641.7	Increase	4913.4	1210.7	Increase	4166.8	2346.6	Increase
il1b	1449399_a_at	2322.7	1027.5	Increase	1919.8	1355.5	Increase	1587.8	1663	No change
il18	1417932_at	1280	941	No change	1722.4	658.9	Increase	1498.4	840.9	Increase
il18r1	1421628_at	2336.8	279.4	Increase	5965.7	2332.4	Increase	10221.2	4810	Increase
il18rap	1456545_at	1326.6	392.7	Increase	3042	1722	Increase	5229.3	4758.1	No change
Il6	1450297_at	115	44.9	No change	20.7	33.6	No change	5888.1	2484.2	Increase
tnf	1419607_at	291.9	195	No change	472.2	253.8	Increase	906.7	551.2	Increase
gzma	1417898_a_at	13097.3	2514.9	Increase	22373.6	11803.6	Increase	32005.9	35300.9	No Change
gzmb	1419060_at	6568.9	1127.1	Increase	17907	6863.3	Increase	14257.1	14818.8	No Change
gzmk	1422280_at	2049.2	400.9	Increase	10278.1	2464.3	Increase	3299.7	1849.7	Increase
prf1	1451862_a_at	677.4	262.8	Increase	3098.3	2575.4	Increase	2369.2	2338.4	No Change
fasl	1449235_at	514.6	232.2	Increase	1198.3	497	Increase	2026	1903.7	No Change
klrc1	1425005_at	1237.6	272.5	Increase	2809.8	1154.7	Increase	9477.8	6187.2	Increase
klrd1	1460245_at	2968.6	1158.5	Increase	12620.7	11113.5	Increase	14710.6	10420.8	Increase
klrg1	1420788_at	2706.3	315.4	Increase	4224.1	1961.4	Increase	6138.2	4830.9	Increase
klrk1	1450495_a_at	1109.5	459.2	Increase	6708.1	2665	Increase	10344.4	8147.4	Increase
cd14	1417268_at	2277.3	1158.6	Increase	2004.7	515	Increase	2112.1	870.8	Increase
cd28	1417597_at	1154.5	742.5	No change	5199.3	3430.5	Increase	2448.6	1127.7	Increase
cd3e	1422105_at	2558.9	1382.3	Increase	5797.7	5959.3	No change	3458.3	3198.7	No change
cd8a	1444078_at	1131	634.3	Increase	12587.6	13751.8	No change	1425.6	2022	Decrease
cd8b1	1426170_a_at	3568.2	1429.2	Increase	27357.8	25575	No change	4259.4	3833.2	No change

*SI stands for “signal intensity.” ** Indicates statistically significant difference between IFNg KO and WT groups.