Identification of Four Potential Epigenetic Modulators from the NCI Structural Diversity Library Using a Cell-Based Assay

Table 2

Characterization of the anticancer properties of hits. Cell viability assays were performed with hits from the assay, and IC₅₀ values were obtained for several nonsmall cell lung cancer cell lines and several melanoma cell lines (bold).

Drug ID	Cell Line	IC50(μM)
NSC-22225/NSC-22206	H1395	>20
	H1437	>10
	H358	>10
	Mel270	>5
	OCM3	>5
NSC-150117	H1395	2.3
	H1437	>10
	H358	1.9
	Mel270	1.7
	OCM1	3.4
	OCM3	2.2
	Omm1	0.5
	Omm2.3	1.7
NSC-693322	H1395	>10
	H1437	>10
	H358	8.7
	Mel270	1.5
	Mel285	1.7
	OCM1	1.4
	OCM3	2.9
	Omm1	0.1
	Omm2.3	0.3
NSC-159631	H1395	0.4
	H1437	0.7
	H358	0.6
	HCC4018	0.4
	Mel270	0.5
	Mel285	0.8
	OCM1	0.7
	OCM3	0.3
	Omm2.3	0.5