Functions of MDMX in the Modulation of the p53-Response
Figure 3
The ratio between mdmx-S and mdmx-fl mRNA is increased by various types of DNA damage and by inhibition of nuclear export. RT-PCR analysis of RNAs extracted from various cell lines, treated for the indicated time periods with a variety of agents. The mdmx-specific PCR primers are located in exon 3 and exon 8. The doses genotoxic/drug treatments used: UV-C: 15 J/m2; cisplatin: 30 μM; LMB (Leptomycin B): 10 nM; Eto (Etoposide): 20 μM; Nutlin-3: 10 μM.
