BioMed Research International / 2011 / Article / Tab 1

Review Article

Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy

Table 1

The physiological role of class I and class IIa HDACs in cardiac development and heart diseases.

HDAC subtypeModelPhenotypeDisease functions in the heartReferences

HDAC1P19CL16 cellsDifferentiationHDAC1 protein was decreased during cardiomyogenesisLiu et al. [23]
HDAC1-deficient miceProliferationEmbryo lethality because of proliferation defectsLagger et al. [24],
Montgomery et al. [25]

HDAC2HDAC2 knockout miceProliferationProliferation rates of cardiac myocytes in HDAC2 knockout mice were elevatedTrivedi et al. [26]
HDAC2 knockout miceProliferationIncrease in proliferation at P1Lethality after P1Montgomery et al. [25]
HDAC2 knockout miceHypertrophyHDAC2 knockout mice are resistant to cardiac hypertrophyTrivedi et al. [26]
HDAC2 transgenic miceHypertrophyHDAC2 transgenic mice show cardiac hypertrophyTrivedi et al. [26]
Aortic banding miceHypertrophyHDAC2 and HSP70 cause cardiac hypertrophyKee et al. [14]
Hsp70 knockout mice

HDAC3HDAC3 transgenic miceProliferationHDAC3 transgenic mice show postnatal cardiac myocyte proliferationTrivedi et al. [27]
HDAC3 knockout miceHypertrophyHDAC3 knockout mice show massive cardiac hypertrophyMontgomery et al. [28]
HDAC3 knockout miceMetabolismHDAC3 regulates cardiac energy metabolismMontgomery et al. [28]

HDAC4HDAC4 knockout miceHDAC4 knockout mice die perinatally because of abnormal chondrocyte hypertrophyVega et al. [29]

HDAC5HDAC5 knockout miceHypertrophyMice lacking HDAC5 develop enlarged hearts in response to pressure overloadChang et al. [30]

HDAC9HDAC9 knockout miceHypertrophyHDAC9 mutant mice develop cardiac hypertrophyZhang et al. [31]