|
Subtype used | | | | |
Priming | Challenge | Species | Experiment | Comments | Ref |
|
H1N1 | H1N1 | Mouse | Adoptive transfer | Splenocytes depleted from CD8+ T cells failed to protect against infection. | [25] |
H1N1 or H3N2 | H1N1 or H3N2 | Mouse | Adoptive transfer | T cells afford protection against infection with heterosubtypic strain. | [48] |
H3N2 | H3N2 | Nude mouse | Adoptive transfer | Immune spleen cells from Balb-c mice mediated more rapid clearance of virus infection and correlated with cytolytic activity. | [49] |
H3N2 | H1N1 H3N2 H2N2 | Mouse | Adoptive transfer | Mouse NP-specific CTL clone afforded protection. | [50] |
NP from H3N2 | H1N1 | Mouse | | NP priming promoted recovery and was attributed to cross-reactive CTLs. | [51] |
H2N2 | H1N1 | Mouse | Adoptive transfer | Cross-reactive CTL clones conferred protection. | [52] |
H3N2 | H3N2 | Mouse | Adoptive transfer | NP-specific CTL clone reduced lung virus titers and mortality rates. | [53] |
H1N1 | H3N2 | Mouse | Depletion of T cells | CTLs conferred heterosubtypic immunity and reduced virus titers in the respiratory tract. | [54] |
H3N2 | H1N1 | Mouse | | Protection correlated with CTL response. | [45] |
H9N2 | H5N1 | Mouse | | Protection correlated with CTL response to NP or PB2. | [46] |
H1N1 | H2N2 | Mice KO for Ig or γ/δ T cells | Acute depletion of CD8+ T cells | In absence of Ig or T cells, CTLs conferred protection. | [44] |
H1N1 | H3N2 | Mouse | | Protection correlated with CTL response to NP. | [43] |
H3N2 | H5N1 | Mouse | | Protection correlated with CTL response to NP and PA. | [42] |
Gamma-irradiated viruses | H1N1 | Mouse | Adoptive transfer of CD8+ T cells | CTL but not B cells afforded protection. | [36] |
H3N2 | 2009 pH1N1 | Mouse | Depletion of CD8+ T cells | CTL conferred heterosubtypic immunity to 2009 pH1N1 virus. | [55] |
H3N2 | 2009 pH1N1 | Mouse | Adoptive transfer of CD8+ and CD4+ T cells | CTL conferred heterosubtypic immunity to 2009 pH1N1 virus. | [22] |
|
H9N2 | H5N1 | Chicken | Adoptive transfer of CD8+ T cells | CTLs reduced mortality rates. | [56] |
H9N2 | H5N1 | Chicken | Depletion | CTLs reduced mortality rates. | [57] |
|
H3N2 | H5N1 | Ferret | | Protection correlated with CTL response. | [58] |
|
| H1N1 | Human | | CTL activity correlated with protection in absence of antibodies. | [37] |
|