Cervicovaginal Safety of the Formulated, Biguanide-Based Human Immunodeficiency Virus Type 1 (HIV-1) Inhibitor NB325 in a Murine Model

Figure 3

Short exposures to 1% unformulated NB325 result in isolated damage to the vaginal epithelium. Mice were exposed to 1% unformulated NB325 for 10 min, 2 h, or 4 h prior to sacrifice and cervicovaginal tissue isolation. H&E-stained vaginal ((a), (c), (e)) and cervical ((b), (d), (f)) tissue sections were analyzed for epithelial damage. Representative micrograph fields for each exposure are shown. Images are representative of three mice per exposure duration.