Cervicovaginal Safety of the Formulated, Biguanide-Based Human Immunodeficiency Virus Type 1 (HIV-1) Inhibitor NB325 in a Murine Model

Figure 7

Cervicovaginal epithelial integrity after exposure to 1% formulated NB325 for 8 h or 24 h is similar to that of controls. Mice were exposed to 1% formulated NB325 for 8 h or 24 h prior to sacrifice and isolation of reproductive tract tissues. H&E-stained tissue sections were analyzed for toxicity to the vaginal ((a), (c)) and cervical ((b), (d)) epithelia. Representative micrograph fields for each exposure are shown. Images are representative of three mice per exposure duration.