Surgical Approaches to Create Murine Models of Human Wound Healing

Table 1

Major differences between mouse and human skin.

	Mouse	Human
Hair cycle	Approximately 3 weeks	Highly variable, region-dependent
Epithelial architecture	No rete ridges	Rete ridges present
Apocrine sweat glands	Not present in skin, extensive in mammary glands	Present in axilla, inguinal, and perianal skin regions
Biomechanical properties	Thin, compliant, loose	Thick, relatively stiff, adherent to underlying tissues
Hypodermal thickness	Hair cycle-dependent	Less variable
Subcutaneous muscle layer	Present throughout as panniculosus carnosus	Present only in neck region as platysma
Major method of wound healing	Contraction	Granulation tissue formation and re-epithelialization