The Tale of Protein Lysine Acetylation in the Cytoplasm

Table 2

Lysine (K) deacetylases.

Name	Localisation	Cytoplasmic substrates
Class I
HDAC1	mainly nucleus
HDAC2	nucleus
HDAC3	mainly nucleus/cytoplasm
HDAC8	mainly cytoplasm
class IIa
HDAC4	cytoplasm/nucleus	MLP, DNAJB8
HDAC5	cytoplasm/nucleus
HDAC7	cytoplasm/mitochondria/nucleus
HDAC9	cytoplasm/nucleus
Class IIb
HDAC6	cytoplasm	tubulin, cortactin, Hsp90, β-catenin, peroxiredoxin
HDAC10	cytoplasm/nucleus
Class IV
HDAC11	mainly nucleus
Class III(sirtuins)
sirt1	cytoplasm/nucleus	cortactin, Atg5, Atg7, Atg8
sirt2	cytoplasm	tubulin, cortactin?
sirt3	mitochondria/long form cytoplasm
sirt4	mitochondria
sirt5	mitochondria
sirt6	nucleus
sirt7	nucleus