Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine: Vaccinia Tiantan Strain
Figure 2
Anti-S neutralizing antibody responses in VTT-vaccinated mice after two MVTT-S challenges. (a) Serum samples of i.m., i.n., and i.o. VTT-vaccinated as well as of placebo-inoculated (no VTT) mice were tested. (b) Serum samples of s.c. VTT-vaccinated mice were tested. Pooled sera, which contain an equal amount of serum of each vaccinated mouse in each group, were subjected to each experiment. The -axis represents the serum dilution factor whereas the -axis indicated the percentage of viral inhibition. The dashed horizontal line indicates IC50 values. The experiment was repeated twice with similar results obtained.
