Novel Image Analysis Approach Quantifies Morphological Characteristics of 3D Breast Culture Acini with Varying Metastatic Potentials
Figure 4
Features quantifying acinus and hollow lumens morphology are statistically significant between cell lines and states of health. (a) shows the number of nuclei per acinar structure, (b) shows the acinar structure elongation (roundness) that is measured as illustrated in (d) where the ratio between the minor and major axis of the ellipse fitted to the acinar structure is taken, and (c) shows the ratio between the hollow lumen and acinar structure areas that is computed as illustrated in (e). Error bars correspond to the standard error of the means. Two-sided -tests were performed and cell lines that exhibit statistically significance () are marked with asterisks (*).
