Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy
Figure 5
Quantitation of CNFs. We counted CNFs in H&E-stained cross sections of uninjured and injured TA muscles. In uninjured muscles, CNFs were elevated in all dysferlin mutants, with SJL/J muscle showing the greatest elevation. DMDmdx muscle showed several-fold CNFs more than all the dysferlinopathic samples. Except for DMDmdx, none of the strains showed changes in CNFs at D3. *Significant difference compared to control strain at same time point. #Significant difference within same strain between uninjured and D3. †Significant difference compared to same Dysf mutation at same time point. ‡Significant difference compared to A/J at same time point. NS:no significant difference.
