Human L-Ficolin (Ficolin-2) and Its Clinical Significance

Table 1

The human ficolins.

	M-ficolin	L-ficolin	H-ficolin
Molecular size (subunit)	35 K	35 K	34 K
Molecular size (native)	900 K	420 K	610 K
Location	Neutrophils, monocytes > serum	liver; serum	liver; bile; lung; serum
Chemical specificity	Acetylated sugars	acetylated compounds; LPS; 1,3-β-glucans; lipoteichoic acids; elastin; steroids	D-fucose > GlcNAc; polysaccharide from A.viridans
Microbial specificity	E. coli; S. aureus;  S. agalactiae	S. aureus; S. pneumoniae; S. typhimurium; E. coli; P. aeruginosa; M. bovis; G. lamblia; T. cruzi; A. fumigatus,	A. viridans; T. cruzi
Complement activation	Yes	Yes	Yes
Opsonic activity	?	Yes	?
Collagenase sensitivity	Yes	Yes	No