Figure 2: Interaction of α-enolase with other nuclear, cytoplasmic, or membrane molecules. α-Enolase can directly interact with other enolase isoforms (α, β, and γ) to form enzymatically active dimers, other glycolytic enzymes as pyruvate kinase, phosphoglycerate mutase and aldolase. It can also bind to microtubules network proteins, as F-actin and tubulin, and it is localized on the cell surface, interacting with other membrane proteins, where it binds to plasminogen and plasmin.