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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 157496, 5 pages
http://dx.doi.org/10.1155/2012/157496
Review Article

Bone Marrow Microenvironment in Multiple Myeloma Progression

1Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avnue, HIM 246, Boston, MA 02215, USA
2Service des Maladies du Sang, CHRU de Lille, 59000 Lille, France

Received 3 August 2012; Accepted 18 September 2012

Academic Editor: Sue-Hwa Lin

Copyright © 2012 S. Manier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche.