Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility

Table 2

The concentration (ED₅₀) eliciting 50% of maximum contraction induced by local anesthetics in endothelium-denuded aorta.

Local anesthetics	N	Log ED50	Contraction induced by 60 mM KCl (g)
Levobupivacaine	6	−4.65 ± 0.08	2.94 ± 0.66
Ropivacaine	6	−4.11 ± 0.07^*	3.24 ± 0.51
Lidocaine	6	−3.74 ± 0.15^*,†	2.88 ± 0.49
Mepivacaine	6	−3.20 ± 0.07^*,†,‡	2.91 ± 0.36

Values are expressed as mean ± SD.
N: number of rats.
^*P < 0.001 versus levobupivacaine, ^†P < 0.001 versus ropivacaine, ^‡P < 0.001 versus lidocaine.