Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex
Figure 2
(a) The scores of crossings of rats during open-field tests. Ketamine administered at the dose of 10 mg/kg did not affect the scores of crossings, and pretreatment with 5 mg/kg tramadol did not affect any changes of scores of crossings . (b) The scores of rearings of rats during open-field tests. Ketamine administered at the dose of 10 mg/kg did not affect the scores of rearings, and pretreatment with 5 mg/kg tramadol did not affect any changes of scores of rearings .
