Table 1: Impact of ectonucleotidases on solid organ transplantation and allo-HCT.

ModelEctonucleotidaseBiological impactReference

Cardiac xenograft transplantationCD39Attenuated survival of CD39-deficient xenografts in a model of delayed xenograft rejection with enhanced parenchymal injury, infarction and platelet aggregation[4]
Cardiac xenograft transplantationCD39Increased intravascular platelet sequestration and focal myocardial infarction in complement-depleted, presensitized 𝐶 𝑑 3 9 / recipients[42]
Cardiac xenograft transplantationCD39Adenovirus-mediated CD39 overexpression leads to significantly prolonged xenograft survival with reduced vascular thrombosis[43]
Cardiac allograft/discordant xenograft transplantationCD39Attenuated platelet deposition with preserved cardiac architecture and improved graft survival in mice overexpressing hCD39[44]
Murine allogeneic skin transplantation with adoptive Treg transferCD39CD39-deficient Tregs fail to suppress skin allograft rejection[45]
Murine syngeneic kidney transplantationCD39Reduced acute tubular necrosis and apoptosis, improved graft function and prolonged survival in hCD39 overexpressing isografts[46]
Murine allogeneic cardiac transplantationCD73Reduced graft survival and more severe cardiac allograft vasculopathy when donor or recipient is CD73-deficient[47]
Murine allogeneic tracheal transplantationCD73 𝐶 𝑑 7 3 / recipients show significantly reduced allograft survival with increased airway luminal obliteration and T-cell infiltration[48]
Murine allogeneic hematopoietic cell transplantationCD73CD73 deficiency of donor or recipient enhances acute GvHD severity and pharmacologic CD73 blockade improves GvL activity[49]
Murine allogeneic hematopoietic cell transplantationApyrase treatmentReduced acute GvHD severity, T cell expansion, IFN-γ production and increased Treg numbers[50]
Cardiac xenograft transplantationApyrase treatmentAttenuated intragraft platelet aggregation and prolonged survival time[51]
Rat syngeneic lung transplantationApyrase treatmentProtection against pulmonary edema, improved oxygenation, attenuated neutrophil activity, apoptosis, and inflammatory cytokine production[52]