Efficacy of Continuously Administered PEDF-Derived Synthetic Peptides against Osteosarcoma Growth and Metastasis

Table 1

Tumour per cent necrosis and apoptosis as determined on haematoxylin and eosin-stained and TUNEL-stained sections of orthotopic tumour, respectively.

	Water	StVOrth-2 50 μg/kg/day	StVOrth-2 500 μg/kg/day	StVOrth-3 50 μg/kg/day	StVOrth-3 500 μg/kg/day
% Necrosis	28.2%	31.3%	8.9%	46.6%	33.5%
	(±8.01 SEM)	(±11.85 SEM) 𝑃>0.05	(±2.952 SEM) 𝑃>0.05	(±10.04 SEM) 𝑃>0.05	(±4.071 SEM) 𝑃>0.05
% Apoptosis	20.2%	15.9%	3.6%	39.4%	41.3%
	(±2.22 SEM)	(±1.87 SEM)  𝑃>0.05	(±0.56 SEM)  𝑃>0.05	(±13.89 SEM)  𝑃>0.05	(±10.12 SEM)  𝑃>0.05