Effect of Plasminogen Activator Inhibitor-1 and Tissue Plasminogen Activator Polymorphisms on Susceptibility to Type 2 Diabetes in Malaysian Subjects
Association of PAI-1 4G/5G polymorphisms with type 2 diabetes mellitus in Malaysian subjects.
PAI-1 4G/5G polymorphism
Type 2 diabetes mellitus
Total type 2 diabetes mellitus ()
Without MetS ()
With MetS ()
Risk allele frequency (4G)
In the additive model, genotype of homozygote for the nonrisk allele 5G/5G (0/0), heterozygote 4G/5G (1/0), and homozygote for the risk allele 4G/4G (1/1) were coded as 0, 1, and 2, respectively. The recessive model was defined as 4G/4G versus (4G/5G + 5G/5G), dominant model as (4G/4G + 4G/5G) versus 5G/5G, and additive model as 4G/4G versus 4G/5G versus 5G/5G. The results presented odds ratio, 95% CI, and value adjusted for age, gender, race, family history of diabetes, and BMI as covariates which evaluated by hierarchical logistic regression. MetS: metabolic syndrome.
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