Effect of Plasminogen Activator Inhibitor-1 and Tissue Plasminogen Activator Polymorphisms on Susceptibility to Type 2 Diabetes in Malaysian Subjects
Association of tPA Alu repeat-I/D polymorphism with type 2 diabetes mellitus in Malaysian subjects.
tPA Alu repeat I/D polymorphism
Type 2 diabetes mellitus
Total type 2 diabetes mellitus ()
Without MetS ()
With MetS ()
Risk allele frequency (Insertion)
In the additive model, genotype of homozygote for the nonrisk allele D/D (0/0), heterozygote I/D (1/0), and homozygote for the risk allele I/I (1/1) was coded as 0, 1, and 2, respectively. The recessive model was defined as I/I versus (I/D + D/D), dominant model as (I/I + I/D) versus D/D and additive model as D/D, versus I/D versus I/I. The results presented odds ratio, 95% CI and -value adjusted for age, gender, race, family history of diabetes and BMI as covariates which evaluated by hierarchical logistic regression. MetS: metabolic syndrome.
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