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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 239091, 6 pages
Review Article

The Emerging Role of PEDF in Stem Cell Biology

Department of Biomedical and Health Sciences, Victoria University, St Albans, VIC 3021, Australia

Received 19 December 2011; Accepted 15 March 2012

Academic Editor: Susan E. Crawford

Copyright © 2012 Mina Elahy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.