Table 3
Drug interactions of artemisinins.
| Drug combination | Cancer/cell line | Effect | Refs |
| DHA + Temozolomide | Rat C6 glioma cells | Increased apoptosis, ROS Induced necrosis | [107] |
| DHA + Cyclophosphamide | Lewis lung carcinoma | Increased apoptosis, decreased VEGF receptor KDR/flk-1 Apoptosis | [84] |
| DHA + Cisplatin | Human non-small cell lung cancer (A549) | Decreased metastasis | [84] |
| DHA + Gemcitabine | Pancreas (Panc-1)
| Inhibition of proliferation, decreased cyclin D1 Increased apoptosis, increased Bax/Bcl2 ratio, activation of caspase 3 | [94] | Hepatoma (cell panel) | Increased growth inhibition by 45% | [67] |
| DHA + Butyric acid | Human lymphoblastoid leukemia (Molt-4) | Synergistic. Depletion of cancer cells | [110] |
| DHA + Radiation | Glioma cells U373MG | Increased cytotoxicity Inhibition of radiation-induced GST | [53] |
| DHA + Carboplatin | Ovarian cancer cells (A2780, OVCAR-3) | Increased growth inhibition through death receptor and mitochondrial mediated pathways | [77] |
| DHA + TRAIL | Prostate cancer (DU145, PC-3, LNCaP) | Increased apoptosis extrinsic and intrinsic pathways | [100] |
| ART/DHA + Doxorubicin + Pirarubicin | Leukemia (K562/adr) Small cell lung cancer (GLC4/adr) | Synergistic | [4] |
| ART + Lenalidomide | Lung (A549) and breast (MCF-7) | Decreased IC50 by 48% | [111] |
| ART + Oxiplatin | Colon (HT 1116) | Additive. Sensitising effect |
[111] | ART + Gemcitabine | Breast (MCF-7) | Additive | | Lung (A549) | Additive |
| ATM + Oxiplatin ATM + Thalidomide ATM + Gemcitabine
| Colon (HCTl16, SW480) Breast (MCF-7) | All additive | [63] |
| ARS + Hyperbaric oxygen (HBO2) | Molt-4 human leukemia | 22% decrease in growth | [112] |
| ARS + Doxorubicin | Colon cancer(HT29) | Predicted as antagonic, mediated by activation of NF-κB/overexpression of Pgp | [59] |
| ARS + Oxiplatin | Colon (HCTl16, SW480) | Antagonism |
[63] | ARS + Thalidomide | Additive | ARS + Gemcitabine | Breast (MCF-7) | Antagonism |
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Abbreviations: HBO2: hyperbaric oxygen.
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