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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 249129, 11 pages
http://dx.doi.org/10.1155/2012/249129
Research Article

The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque

1Office building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, China
2Tianjin University of Traditional Chinese Medicine, Tianjin, China

Received 21 March 2012; Revised 25 July 2012; Accepted 30 July 2012

Academic Editor: Renata Gorjão

Copyright © 2012 Guangyin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Galkina and K. Ley, “Immune and inflammatory mechanisms of atherosclerosis,” Annual Review of Immunology, vol. 27, pp. 165–197, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. A. C. Doran, N. Meller, and C. A. McNamara, “Role of smooth muscle cells in the initiation and early progression of atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 5, pp. 812–819, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Vinegoni, I. Botnaru, E. Aikawa et al., “Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques,” Science Translational Medicine, vol. 3, no. 84, Article ID 84ra45, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Ross, “Atherosclerosis—an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. G. K. Hansson and P. Libby, “The immune response in atherosclerosis: a double-edged sword,” Nature Reviews Immunology, vol. 6, no. 7, pp. 508–519, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Joner, G. Nakazawa, C. Bonsignore et al., “Histopathologic evaluation of nitinol self-expanding stents in an animal model of advanced atherosclerotic lesions,” EuroIntervention, vol. 5, no. 6, pp. 737–744, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Sigovan, L. Boussel, A. Sulaiman et al., “Rapid-clearance iron nanoparticles for inflammation imaging of atherosclerotic plaque: initial experience in animal model,” Radiology, vol. 252, no. 2, pp. 401–409, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. A. A. Gupte, J. Z. Liu, Y. Ren et al., “Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice,” Hepatology, vol. 52, no. 6, pp. 2001–2011, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Masuda and R. Ross, “Atherogenesis during low level hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque,” Arteriosclerosis, vol. 10, no. 2, pp. 178–187, 1990. View at Google Scholar · View at Scopus
  10. D. E. Karangelis, I. Kanakis, A. P. Asimakopoulou et al., “Glycosaminoglycans as key molecules in atherosclerosis: the role of versican and hyaluronan,” Current Medicinal Chemistry, vol. 17, no. 33, pp. 4018–4026, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. N. S. van Ditzhuijzen, M. van den Heuvel, O. Sorop et al., “Invasive coronary imaging in animal models of atherosclerosis,” Netherlands Heart Journal, vol. 19, no. 10, pp. 442–446, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Nanobashvili, M. Prager, A. Jozkowicz et al., “Positive effect of treatment with synthetic steroid hormone Tibolon on intimal hyperplasia and restenosis after experimental endothelial injury of rabbit carotid artery,” European Surgical Research, vol. 36, no. 2, pp. 74–82, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Ragni, P. Golino, P. Cirillo et al., “Endogenous tissue factor pathway inhibitor modulates thrombus formation in an in vivo model of rabbit carotid artery stenosis and endothelial injury,” Circulation, vol. 102, no. 1, pp. 113–117, 2000. View at Google Scholar · View at Scopus
  14. O. Lazoura, D. Zacharoulis, T. Kanavou et al., “A novel experimental animal model of arterial stenosis based on endovascular radiofrequency energy application,” Journal of Investigative Surgery, vol. 24, no. 3, pp. 123–128, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Zhang, Y. Liu, X. T. Lu et al., “Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy,” American Journal of Physiology, vol. 297, no. 6, pp. H2004–H2014, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Brizzola, M. De Eguileor, T. Brevini et al., “Morphologic features of biocompatibility and neoangiogenesis onto a biodegradable tracheal prosthesis in an animal model,” Interactive Cardiovascular and Thoracic Surgery, vol. 8, no. 6, pp. 610–614, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Acocella, S. Brizzola, C. Valtolina et al., “Prefabricated tracheal prosthesis with partial biodegradable materials: a surgical and tissue engineering evaluation in vivo,” Journal of Biomaterials Science, Polymer Edition, vol. 18, no. 5, pp. 579–594, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Calcagno, J. C. Cornily, F. Hyafil et al., “Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 7, pp. 1311–1317, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Rega, C. Kaun, S. Demyanets et al., “Vascular endothelial growth factor is induced by the inflammatory cytokines interleukin- 6 and oncostatin m in human adipose tissue in vitro and in murine adipose tissue in vivo,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 7, pp. 1587–1595, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Kawasaki, A. Hattori, Y. Ishihara et al., “Tissue characterization of coronary plaques and assessment of thickness of fibrous cap using integrated backscatter intravascular ultrasound—comparison with histology and optical coherence tomography,” Circulation Journal, vol. 74, no. 12, pp. 2641–2648, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Qiao, I. Ronen, J. Viereck, F. L. Ruberg, and J. A. Hamilton, “Identification of atherosclerotic lipid deposits by diffusion-weighted imaging,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 6, pp. 1440–1446, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Liu, X. Wang, K. B. Tan et al., “Molecular imaging of vulnerable plaques in rabbits using contrast-enhanced ultrasound targeting to vascular endothelial growth factor receptor-2,” Journal of Clinical Ultrasound, vol. 39, no. 2, pp. 83–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. J. A. Leopold and J. Loscalzo, “Oxidative risk for atherothrombotic cardiovascular disease,” Free Radical Biology and Medicine, vol. 47, no. 12, pp. 1673–1706, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Shimizu, K. Nakai, Y. Morimoto et al., “Simple rabbit model of vulnerable atherosclerotic plaque,” Neurologia Medico-Chirurgica, vol. 49, no. 8, pp. 327–332, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Xiangdong, L. Yuanwu, Z. Hua, R. Liming, L. Qiuyan, and L. Ning, “Animal models for the atherosclerosis research: a review,” Protein and Cell, vol. 2, no. 3, pp. 189–201, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Matsuda, Y. Suzuki, K. Kondo, Y. Ikeda, and K. Umemura, “Hypercholesterolemia induces regression in neointimal thickening due to apoptosis of vascular smooth muscle cells in the hamster endothelial injury model,” Cardiovascular Research, vol. 53, no. 2, pp. 512–523, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Krebs, E. Scandella, B. Bolinger, D. Engeler, S. Miller, and B. Ludewig, “Chronic immune reactivity against persisting microbial antigen in the vasculature exacerbates atherosclerotic lesion formation,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 10, pp. 2206–2213, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. A. A. Amran, Z. Zakaria, F. Othman, S. Das, S. Raj L, and N. M. M. Nordin, “Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high cholesterolemic experimental rabbits,” Lipids in Health and Disease, vol. 9, article 44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Hakimoǧlu, G. Kizil, Z. Kanay, M. Kizil, and H. Isi, “The effect of ethanol extract of Hypericum lysimachioides on lipid profile in hypercholesterolemic rabbits and its in vitro antioxidant activity,” Atherosclerosis, vol. 192, no. 1, pp. 113–122, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. M. L. Kohut, Y. J. Sim, S. Yu, K. J. Yoon, and C. M. Loiacono, “Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection,” Journal of Infectious Diseases, vol. 200, no. 9, pp. 1434–1442, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Li, J. R. Du, W. D. Wang et al., “Experimental study of effect of tanshinone on artery restenosis in rat carotid injury model,” Zhongguo Zhongyao Zazhi, vol. 31, no. 7, pp. 580–584, 2006. View at Google Scholar · View at Scopus
  32. T. Temma, Y. Ogawa, Y. Kuge et al., “Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model,” Journal of Nuclear Medicine, vol. 51, no. 12, pp. 1979–1986, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. H. J. Park, J. Y. Baek, W. S. Shin et al., “Soluble receptor of advanced glycated endproducts is associated with plaque vulnerability in patients with acute myocardial infarction,” Circulation Journal, vol. 75, no. 7, pp. 1685–1690, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Gordon, W. P. Castelli, and M. C. Hjortland, “High density lipoprotein as a protective factor against coronary heart disease. The Framingham study,” American Journal of Medicine, vol. 62, no. 5, pp. 707–714, 1977. View at Google Scholar · View at Scopus
  35. H. Chen, J. Cai, X. Zhao et al., “Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI,” Magnetic Resonance in Medicine, vol. 64, no. 2, pp. 567–573, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. R Ross, “Atherosclerosis—an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999. View at Google Scholar
  37. J. Fan and T. Watanabe, “Inflammatory reactions in the pathogenesis of atherosclerosis,” Journal of Atherosclerosis and Thrombosis, vol. 10, no. 2, pp. 63–71, 2003. View at Google Scholar · View at Scopus
  38. L. Zhong, W. Q. Chen, X. P. Ji et al., “Dominant-negative mutation of monocyte chemoattractant protein-1 prevents vulnerable plaques from rupture in rabbits independent of serum lipid levels,” Journal of Cellular and Molecular Medicine, vol. 12, no. 6, pp. 2362–2371, 2008. View at Publisher · View at Google Scholar · View at Scopus