Protegrin-1 Inhibits Dengue NS2B-NS3 Serine Protease and Viral Replication in MK2 Cells

Table 1

The parameters of PG-1 Inhibition potential towards NS2B-NS3pro.

Parameter*	Values	Std. Error
𝑉max	0.28 𝜇mol/min	±0.01
Alpha	3.14	±0.81
𝐾𝑖	5.85 𝜇M	±1.82
IC50	11.70 𝜇M	±2.23
𝐾𝑚	109.10 𝜇M	±7.50

^∗𝑉_max: maximum enzyme velocity (𝜇mol/min). 𝐾_𝑚: Michaelis-Menten constant (𝜇M). 𝐾_𝑖: inhibition constant (𝜇M). Alpha: constant that determines mechanism. If alpha = 1, this is the same as noncompetitive. If alpha is very high, then the model approaches a competitive model. If alpha is very low (but greater than zero), the model approaches an uncompetitive model. All parameters were calculated by GraphPad Prism 5.0 software.