Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 267890, 9 pages
http://dx.doi.org/10.1155/2012/267890
Research Article

Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2/TNF 饾浖

1Protein Science Laboratory of the Ministry of Education, Laboratory of Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
2Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
3Drug Discovery Facility, School of Life Sciences, Tsinghua University, Beijing 100084, China

Received 28 July 2011; Revised 31 October 2011; Accepted 22 November 2011

Academic Editor: Ikhlas A. Khan

Copyright 漏 2012 Hui-Ying Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [30 citations]

The following is the list of published articles that have cited the current article.

  • Deliang Yi, Chengtie Wu, Xubing Ma, Heng Ji, Xuebin Zheng, and Jiang Chang, “Preparation and in vitro evaluation of plasma-sprayed bioactive akermanite coatings,” Biomedical Materials (Bristol), vol. 7, no. 6, 2012. View at PublisherView at Google Scholar
  • Yu-Shuang Chai, Fan Lei, Dong-Ming Xing, Yi Ding, and Li-Jun Du, “Effect of baicalin on pattern recognition receptor TLR2/4-NOD2 and its significance of druggability,” Zhongguo Zhongyao Zazhi, vol. 38, no. 16, pp. 2639–2644, 2013. View at PublisherView at Google Scholar
  • Ulaganathan Mabalirajan, Tanveer Ahmad, Rakhshinda Rehman, Geeta Devi Leishangthem, Amit Kumar Dinda, Anurag Agrawal, Balaram Ghosh, and Surendra Kumar Sharma, “Baicalein Reduces Airway Injury in Allergen and IL-13 Induced Airway Inflammation,” PLoS ONE, vol. 8, no. 4, 2013. View at PublisherView at Google Scholar
  • Chingju Lin, Wen-Wen Huang, Tian-Shung Wu, Jai-Sing Yang, Shih-Chang Tsai, Michael T. Tseng, Shu-Fen Peng, Sheng-Chu Kuo, Meng-Wei Lin, Yuan-Man Hsu, Miau-Rong Lee, and Sakae Amagaya, “AKT serine/threonine protein kinase modulates baicalintriggered autophagy in human bladder cancer T24 cells,” International Journal of Oncology, vol. 42, no. 3, pp. 993–1000, 2013. View at PublisherView at Google Scholar
  • Mengyao Guo, Yongguo Cao, Tiancheng Wang, Xiaojing Song, Zhicheng Liu, Ershun Zhou, Xuming Deng, Naisheng Zhang, and Zhengtao Yang, “Baicalin inhibits S. aureus-induced apoptosis by regulating TLR2 and TLR2-related apoptotic factors in the mouse mammary glands,” European Journal of Pharmacology, 2013. View at PublisherView at Google Scholar
  • Bhakta Prasad Gaire, Sang-Kwan Moon, and Hocheol Kim, “Scutellaria baicalensis in stroke management: Nature's blessing in traditional Eastern medicine,” Chinese Journal of Integrative Medicine, vol. 20, no. 9, pp. 712–720, 2014. View at PublisherView at Google Scholar
  • Meng-Yun He, Yuan-Xiong Deng, Qun-Zhi Shi, Xiao-Jie Zhang, and Yuan Lv, “Comparative pharmacokinetic investigation on baicalin and wogonoside in type 2 diabetic and normal rats after oral administration of traditional Chinese medicine Huanglian Jiedu decoction,” Journal of Ethnopharmacology, 2014. View at PublisherView at Google Scholar
  • Deliang Yi, Chengtie Wu, Bing Ma, Heng Ji, Xuebin Zheng, and Jiang Chang, “Bioactive bredigite coating with improved bonding strength, rapid apatite mineralization and excellent cytocompatibility,” Journal of Biomaterials Applications, vol. 28, no. 9, pp. 1343–1353, 2014. View at PublisherView at Google Scholar
  • De-Liang Yi, Cheng-Tie Wu, Xu-Bing Ma, Heng Ji, Xue-Bin Zheng, and Jiang Chang, “A comparative study on vacuum and air plasma sprayed bioactive akermanite coating,” Wuji Cailiao Xuebao/Journal of Inorganic Materials, vol. 29, no. 2, pp. 172–178, 2014. View at PublisherView at Google Scholar
  • Chia-Ming Lu, Lie-Chwen Lin, and Tung-Hu Tsai, “Determination and Pharmacokinetic Study of Gentiopicroside, Geniposide, Baicalin, and Swertiamarin in Chinese Herbal Formulae after Oral Administratio,” Molecules, vol. 19, no. 12, pp. 21560–21578, 2014. View at PublisherView at Google Scholar
  • Francisco Pérez-Cano, Malen Massot-Cladera, Maria Rodríguez-Lagunas, and Margarida Castell, “Flavonoids Affect Host-Microbiota Crosstalk through TLR Modulation,” Antioxidants, vol. 3, no. 4, pp. 649–670, 2014. View at PublisherView at Google Scholar
  • Kun Zou, Enjuan Tong, Yinghui Xu, Xiaoqin Deng, and Lijuan Zou, “Down regulation of mammalian target of rapamycin decreases HIF-1 alpha and survivin expression in anoxic lung adenocarcinoma A549 cell to elemene and/or irradiation,” Tumor Biology, vol. 35, no. 10, pp. 9735–9741, 2014. View at PublisherView at Google Scholar
  • Yugang Wang, Fan Lei, Lijun Du, Yunong Pang, Jun Hu, Yushuang Chai, Hao Wu, and Dongming Xing, “Comparison of berberine and its five analogues on cell viability and COX2 expression during glucoseoxygen deprivation and reperfusion in PC12 cells,” Journal of Chinese Pharmaceutical Sciences, vol. 23, no. 9, pp. 617–625, 2014. View at PublisherView at Google Scholar
  • Matthew Nichols, Jin Zhang, Brian M. Polster, Pia A. Elustondo, Aruloli Thirumaran, Evgeny V. Pavlov, and George S. Robertson, “Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways,” Neuroscience, 2015. View at PublisherView at Google Scholar
  • Huang Xian Ju, Zhou Huan, Jiang Yi, Zheng Mi, and Huang Xian Ju, “Antitoxic effect of baicalin and glycyrrhetic acid on PC12 cells induced by Aconitum brachypodum Diel,” African Journal of Pharmacy and Pharmacology, vol. 9, no. 12, pp. 424–432, 2015. View at PublisherView at Google Scholar
  • Farhan Hussain, Sandeep Mittal, Nirmal Joshee, and Prahlad Parajuli, “Application of Bioactive Compounds from Scutellaria in Neurologic Disorders,” The Benefits of Natural Products for Neurodegenerative Diseases, vol. 12, pp. 79–94, 2016. View at PublisherView at Google Scholar
  • Wenhao Yang, Huatao Li, Xia Cong, Xin Wang, Zhongling Jiang, Qian Zhang, Xiaonan Qi, Shansong Gao, Rongfeng Cao, and Wenru Tian, “Baicalin attenuates lipopolysaccharide induced inflammation and apoptosis of cow mammary epithelial cells by regulating NF-κB and HSP72,” International Immunopharmacology, vol. 40, pp. 139–145, 2016. View at PublisherView at Google Scholar
  • Madhukar Lohani, Mansi Patel, Mohammed Majrashi, Sneha Joshi, Barbara Kemppainen, Vanisree Mulabagal, and Muralikrishnan Dhanasekaran, “Ethnopharmacological Importance of Western Medicinal Herb, Scutellaria lateriflora,” Medicinal Plants - Recent Advances in Research and Development, pp. 37–72, 2016. View at PublisherView at Google Scholar
  • Xiangyu Zhang, Qi Wang, Liubing Qin, Hao Fu, Yourong Duan, Yiwei Fang, and Baoshan Han, “EGF-modified mPEG-PLGA-PLL nanoparticle for delivering doxorubicin combined with Bcl-2 siRNA as a potential treatment strategy for lung cancer,” Drug Delivery, vol. 23, no. 8, pp. 2936–2945, 2016. View at PublisherView at Google Scholar
  • Xue Wu, Haijun Zhang, Jumah Masoud Mohammad Salmani, Rong Fu, and Baoan Chen, “Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors,” Oncotargets And Therapy, vol. 9, pp. 2935–2943, 2016. View at PublisherView at Google Scholar
  • Xiao-yan Wei, Jin-hua Tao, Xiang Cui, Shu Jiang, Da-wei Qian, and Jin-ao Duan, “Comparative pharmacokinetics of six major bioactive components in normal and type 2 diabetic rats after oral administration of Sanhuang Xiexin Decoction extracts by UPLC-TQ-MS/MS,” Journal of Chromatography B, 2017. View at PublisherView at Google Scholar
  • Li Lu, Li Rao, Huanhuan Jia, Jun Chen, Xingyan Lu, Guozhu Yang, Qingnan Li, Kenneth Ka Ho Lee, and Li Yang, “Baicalin positively regulates osteoclast function by activating MAPK/Mitf signalling,” Journal of Cellular and Molecular Medicine, 2017. View at PublisherView at Google Scholar
  • Jin-Bo Cheng, Yuan Dong, Xiao-Heng Li, and Lin Hou, “Innate immune receptors mediated neuroinflammation in nervous system diseases,” Chinese Journal of Pharmacology and Toxicology, vol. 31, no. 11, pp. 1075–1083, 2017. View at PublisherView at Google Scholar
  • Liang Wei, Huang Xiaobo, and Chen Wenqiang, “The Effects Oo Baicalin and Baicalein on Cerebral Ischemia: A Review,” Aging and Disease, vol. 8, no. 5, pp. 0, 2017. View at PublisherView at Google Scholar
  • Shu Liu, Jun-Peng Xing, Zhi-Qiang Liu, Xue-Ju Zhang, and Feng-Rui Song, “Effect of type 2 diabetes mellitus on flavonoid pharmacokinetics and tissue distribution after oral administration of Radix Scutellaria extract in rats,” Chinese Journal of Natural Medicines, vol. 16, no. 6, pp. 418–427, 2018. View at PublisherView at Google Scholar
  • Tian Xu, Chongyang Ma, Shuning Fan, Nang Deng, Yajun Lian, Ling Tan, Weizhe Du, Shuang Zhang, Shuling Liu, Beida Ren, Zhenhan Li, Qinguo Wang, Xueqian Wang, and Fafeng Cheng, “Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach,” Evidence-Based Complementary and Alternative Medicine, vol. 2018, pp. 1–11, 2018. View at PublisherView at Google Scholar
  • Gaetano Isola, Marco Matarese, Luca Ramaglia, Vincenzo Iorio-Siciliano, Giancarlo Cordasco, and Giovanni Matarese, “Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: a randomized, triple-blind, controlled clinical trial,” Clinical Oral Investigations, 2018. View at PublisherView at Google Scholar
  • Xueju Zhang, Shu Liu, Junpeng Xing, Zifeng Pi, Zhiqiang Liu, and Fengrui Song, “Systematic study on metabolism and activity evaluation of Radix Scutellaria extract in rat plasma using UHPLC with quadrupole time-of-flight mass spectrometry and microdialysis intensity-fading mass spectrometry,” Journal of Separation Science, 2018. View at PublisherView at Google Scholar
  • Zhe Zhang, Guo Ma, Caifu Xue, Hong Sun, Ziteng Wang, Xiaoqiang Xiang, and Weimin Cai, “Establishment of rat liver microsome-hydrogel system for in vitro phase II metabolism and its application to study pharmacological effects of UGT substrates,” Drug Metabolism and Pharmacokinetics, 2019. View at PublisherView at Google Scholar
  • Li Liu, Yu Dong, Xin Shan, Lin Li, Baomei Xia, and Hanqing Wang, “Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo,” Molecules, vol. 24, no. 2, pp. 326, 2019. View at PublisherView at Google Scholar