Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2/TNF𝛼

Table 1

Values of CC₅₀ and EC₅₀ of baicalin, baicalein, wogonoside, and wogonin.

Compounds	CC50	EC50	SI
	μg/mL (mmol/L)	μg/mL (mmol/L)
Baicalin	188.4 (0.422)	1.2 (0.0027)	156
Wogonoside	13.7 (0.0298)	7.4 (0.0161)	1.85
Baicalein	8.9 (0.0329)	1.0 (0.0037)	8.89
Wogonin	10.6 (0.0373)	4.3 (0.0151)	2.47

CC₅₀ means the 50% cytotoxic concentration.
EC₅₀ means the 50% effective concentration.
SI (the safety index) was calculated by CC₅₀/EC₅₀.