Pharmacokinetic Models for FcRn-Mediated IgG Disposition
Figure 2
Cutoff model fitting of plasma 7E3 PK data that were simulated using Hansen’s models. (a) Rat 7E3 PK data fitting at indicated dose levels without IVIG. (b) Rat 7E3 PK data fitting when 8 mg/kg 7E3 were dosed concomitant with IVIG of indicated dose levels. (c) Mouse 7E3 PK data fitting when 8 mg/kg 7E3 was given to FcRn WT or KO mice, with or without 1 g/kg IVIG.
