Pharmacokinetic Models for FcRn-Mediated IgG Disposition

Figure 8

Comparison of 𝑓_𝑈 values derived from IgG concentrations in endosome and plasma using Hansen’s rat model after a single IV dose of 8 mg/kg 7E3 in the presence or absence of IVIG. Significant counter clockwise hysteresis was observed due to IgG distribution delays. In the absence of IVIG, the line visually collapsed into a short line at the ending point of the counter-clockwise hysteresis loop as the lack of significant change in total IgG level kept 𝑓_𝑈 relatively constant.