The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis
Figure 7
Role of S100A10 in Tumor Formation. HT1080 fibrosarcoma cells (106 cells) were injected intradermally into SCID mice and dissected and weighed after 20 days. Thirteen mice were used in each group. The dissected-20 day tumors were photographed. 7/13 of mice injected with S100A10 antisense HT1080 cells developed tumors compared to 100% tumor development for the WT HT1080 cells. Furthermore, the tumors grown by the S100A10-depleted HT1080 cells were much smaller. The data shows that the loss of S100A10 from the cancer cell surface and the resultant loss of protease activity inhibited tumor growth.
