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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 359647, 7 pages
http://dx.doi.org/10.1155/2012/359647
Research Article

Urinary TWEAK Level as a Marker of Lupus Nephritis Activity in 46 Cases

1Division of Nephrology, The Second Xiangya Hospital, Central South University, Changsha 410011, China
2Kidney Institute of Central South University, The Second Xiangya Hospital, 139 Renmin Road, Hunan, Changsha 410011, China

Received 23 March 2012; Revised 13 April 2012; Accepted 13 April 2012

Academic Editor: Sergio O. De Paula

Copyright © 2012 Zhu Xuejing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. This study is designed to observe the urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in patients with lupus nephritis (LN) and to identify new biomarker of lupus nephritis activity. Methods. Study subjects were 46 cases of patients with LN (including 34 of active cases) who underwent routine renal biopsy. Activity and chronicity indexes of LN were assessed using pathological criteria proposed by Hill et al. in 2000. Urinary TWEAK (uTWEAK) level and Monocyte chemoattractant protein-1 (MCP-1) level were detected by ELISA. Results. Urinary TWEAK level was significantly higher in active LN group than in non-active LN group. Correlation analysis showed that urinary TWEAK levels were significantly correlated with activity index ( 𝑟 = 0 . 8 2 5 , 𝑃 < 0 . 0 1 ), glomerular activity index ( 𝑟 = 0 . 7 5 4 , 𝑃 < 0 . 0 1 ), and tubulointerstitial qualitative activity index ( 𝑟 = 0 . 7 5 1 , 𝑃 < 0 . 0 1 ), while not significant correlated with chronicity Index ( 𝑃 > 0 . 0 5 ). The association between urinary TWEAK levels and urinary MCP-1 levels were significant in active LN group ( 𝑟 = 0 . 8 0 9 , 𝑃 < 0 . 0 1 ) but not significant in non-active LN group ( 𝑃 > 0 . 0 5 ). Conclusions. uWEAK levels were correlated with all active indexes of LN, suggesting its potential role as novel biomarker of active lupus nephritis.