BioMed Research International / 2012 / Article / Tab 3 / Research Article
1
1
1
I
n
-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor AngiogenesisTable 3 Biodistribution results for 111 In-DOTA-AgRP-6E in nude mice bearing subcutaneous U87MG human glioblastoma xenografts. Data are expressed as the percent %ID/g after intravenous injection of the probe (0.296–0.444 MBq, 8–12 μ Ci) at 0.5, 2, and 24 h (
𝑛
=
3
).
Tissue 0.5 h 2 h 24 h %ID/g Tumor
1
.
7
6
±
0
.
3
4
1
.
2
1
±
0
.
2
1
0
.
8
9
±
0
.
0
6
Brain
0
.
0
6
±
0
.
0
1
0
.
0
2
±
0
.
0
1
0
.
0
2
±
0
.
0
1
Blood
1
.
2
7
±
0
.
5
3
0
.
0
6
±
0
.
0
5
0
.
0
1
±
0
.
0
0
Heart
0
.
8
0
±
0
.
2
4
0
.
1
8
±
0
.
0
6
0
.
1
2
±
0
.
0
2
Lung
1
.
8
6
±
0
.
5
6
0
.
5
4
±
0
.
1
2
0
.
2
7
±
0
.
0
2
Liver
0
.
8
7
±
0
.
2
0
0
.
5
2
±
0
.
0
1
0
.
4
8
±
0
.
0
2
Spleen
1
.
3
6
±
0
.
2
6
0
.
8
3
±
0
.
0
5
0
.
6
5
±
0
.
0
6
Kidneys
1
5
.
3
7
±
3
.
1
9
1
4
.
6
8
±
1
.
9
8
6
.
8
7
±
1
.
1
9
Muscle
0
.
6
4
±
0
.
0
9
0
.
1
5
±
0
.
0
7
0
.
0
7
±
0
.
0
1
Pancreas
0
.
5
7
±
0
.
2
3
0
.
2
0
±
0
.
0
6
0
.
1
4
±
0
.
0
1
Bone
1
.
1
8
±
0
.
1
5
0
.
5
6
±
0
.
1
0
0
.
3
6
±
0
.
0
4
Stomach
2
.
0
2
±
0
.
4
7
0
.
8
7
±
0
.
1
4
0
.
5
3
±
0
.
0
2
Intestine
2
.
0
4
±
0
.
5
4
1
.
1
3
±
0
.
1
4
0
.
9
3
±
0
.
0
4
Ratio Tumor-to-blood
1
.
7
1
±
1
.
2
1
3
3
.
0
4
±
2
3
.
2
8
1
4
2
.
3
2
±
3
.
3
9
Tumor-to-muscle
2
.
7
5
±
0
.
2
8
9
.
2
0
±
3
.
8
8
1
3
.
0
7
±
1
.
9
4
Data are presented as mean ± SD (
𝑛
=
3
).
