Small Interference RNA Targeting TLR4 Gene Effectively Attenuates Pulmonary Inflammation in a Rat Model

Figure 5

Effects of Ad-siTLR4 on LPS-induced ALI. Lungs were collected at 4 h after injection of normal saline or LPS for histological examination (a, b, c). Sections were stained with hematoxylin-eosin. Magnification: ×100 Wet/Dry ratio (d), total protein content in BALF (e) as well as MPO activity (f) were measured to determine the lung edema, microvascular permeability, and neutrophil sequestration, respectively. ^∗𝑃<0.05 versus Ad-EGFP group, ^#𝑃<0.05 versus control group.

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