Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes

Figure 4

Class II deacetylases orthologues in trypanosomatids. Alignment of the core deacetylase domain from different organisms. Sequences were aligned using ClustalX and were adjusted manually and illustrated with ESPript 2.2. The black boxes indicate the class-specific motif. Identical residues are white on red background, and residues shared by some organisms are black on yellow background. Asterisks indicate residues that were predicted to form part of the catalytic pocket, whereas triangles indicate zinc cofactor ligands. Tb, Trypanosoma brucei; Tc, Trypanosoma cruzi; Lm, Leishmania mayor; At, Arabidopsis thaliana; Hs, human; Sc, Saccharomyces cerevisiae; Sy, Synechocystis spp.; AphaA, acetylpolyamine aminohydrolase.