Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes

Table 2

Lysine acetyltransferases (KATs) present in Tritryps.

Acetyltransferase	Accession numbers			Family	Subcellular localization	Comments	Reference
	T. brucei	L. major	T. cruzi
HAT1	Tb927.7.4560	LmjF14.0140	Tc00.1047053506605.160 Tc00.1047053511239.150	MYST	Nuclear (T. brucei)	Essential for growth, required for telomeric silencing	Kawahara et al., 2008 [34]
HAT2	Tb11.01.3380	LmjF28.2270	Tc00.1047053511017.69 Tc00.1047053509203.60	MYST	Nuclear (T. brucei)	Essential for growth, responsible for H4K10 acetylation	Kawahara et al., 2008 [34]
HAT3	Tb927.10.8310	LmjF36.6990	Tc00.1047053507611.290 Tc00.1047053507723.110	MYST	Nuclear (T. brucei)	Not essential for growth, responsible for H4K4 acetylation	Kawahara et al., 2008 [34]
HAT4		LmjF13.0170	Tc00.1047053506227.160	MYST	Cytoplasmic in all life cycle stages, nuclear in postmitotic cells (L. donovani)	Acetylates histone H4	Kumar et al., 2012 [35]
ELP3a	Tb927.8.5770	LmjF16.0240	Tc00.1047053506743.120 Tc00.1047053503851.10	GNAT	Nuclear periphery (T. brucei)		Alsford and Horn, 2011 [36]
ELP3b	Tb927.8.3310	LmjF23.1350	Tc00.1047053509769.110	GNAT	Nucleolar (T. brucei)	Controls rDNA transcription	Alsford and Horn, 2011 [36]